小于32孕周早产儿静脉用布洛芬治疗动脉导管未闭疗效及影响因素
稿件作者：王欣宁;余加林;肖甜甜;
作者单位：重庆医科大学附属儿童医院
中文摘要：目的：探讨小于32孕周早产儿（very preterm，VP）静脉用布洛芬治疗动脉导管未闭（PDA）疗效及其影响因素。方法：回顾性分析87例静脉用布洛芬治疗PDA的VP。分为治疗成功组和失败组，比较两组间出生孕周、体重、新生儿临床危险指数（CRIB）、治疗前各系统疾病、超声心动图结果、诊断和开始治疗的日龄、疗程和其他治疗等情况。结果：治疗1个疗程、追加1~2次剂量和第2疗程后成功率分别为42.52%（37/87）、68.97%（10/87）和75.86%（66/87）。出生孕周、体重、CRIB>5、治疗前重度呼吸窘迫综合症（NRDS）、肾功能不全发生率、动脉导管直径与体重比、左心房与主动脉根部内径比、首次用药时间等指标两组间差异有统计学意义（P<0.05）。但多因素Logistic回归中仅发现出生体重、CRIB和NDRS情况对PDA的关闭效果有影响。结论：VP中低出生体重和NRDS会降低PDA布洛芬治疗成功率。
关键字词：早产儿；动脉导管未闭；布洛芬
研究领域：新生儿疾病
图文分类：R722
基金支持：
稿件页码：
Effect and Correlative Factors for Intravenous Ibuprofen Treatment on PDA in Very Preterm
英文摘要：Objective: To evaluate the effect and correlative factors of intravenous ibuprofen in treatment of patent ductus arteriosus (PDA) in very preterm (VP) less than 32 weeks of gestational age. Methods: Retrospective study on 87 intravenous ibuprofen treated VPs who divided into “success” and “failure” groups. The two groups were compared in birth gestational age, weight, Clinical Risk Index for Babies (CRIB), complication and ultrasound cardiogram outcome before the treatment, date of treatment, course and additional therapies. Results: The success ratios after 1st course, 1~2 dose supplement and 2ed course were respectively 42.52% (37/87), 68.97% (10/87) and 75.86% (66/87). Birth gestational age, weight, CRIB>5, severe neonatal respiratory distress syndrome (NRDS), renal insufficiency, ductus diameter/weight, left atrial /aortic root, date of first dose were different between the two groups (P<0.05). But multi-factors Logistic Regression find only birth weight, CRIB and NRDS were the correlative factors. Conclusions: Low weight and NRDS after birth could decrease the effect of ibuprofen on PDA medical treatment.
关键字词：Very Preterm; Patent ductus arteriosus; ibuprofen